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ea0029p1611 | Thyroid (non-cancer) | ICEECE2012

Frequency of PDE8B gene polymorphisms in patients affected by sporadic and familiar nonautoimmune subclinical hypothyroidism

Agretti P. , Ferrarini E. , De Marco G. , Dimida A. , Molinaro A. , Niccolai F. , Pinchera A. , Vitti P. , Tonacchera M.

Background: Nonautoimmune subclinical hypothyroidism is characterized by elevated serum levels of TSH in the presence of normal thyroid hormone levels and absence of anti-thyroid antibodies. As a result of a genomic-wide study, a strong association between three polymorphic variants in exon 1 of human phosphodiesterase 8B (PDE8B) gene (rs4704397, rs6885099 e rs2046045) and serum levels of TSH has been recently reported. The aim of the present study was to evaluate the frequenc...

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ea0029p1612 | Thyroid (non-cancer) | ICEECE2012

MicroRNA expression profile helps to distinguish benign and malignant thyroid nodules starting from cells of fine needle aspiration

Agretti P. , Ferrarini E. , Rago T. , Candelieri A. , De Marco G. , Dimida A. , Niccolai F. , Molinaro A. , Di Coscio G. , Pinchera A. , Vitti P. , Tonacchera M.

Objective: MicroRNAs (miRNAs) are small endogenous non-coding RNAs that pair with target messengers regulating gene expression. They are involved in biological processes including development, organogenesis, tissue differentiation, cell cycle and metabolism. Changes in miRNA levels occur in human cancers, including thyroid cancer. Fine needle aspiration (FNA) with cytologic evaluation is the most reliable tool for malignancy prediction in thyroid nodules, but cytologic diagnos...

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Endocrine Abstracts

Frequency of PDE8B gene polymorphisms in patients affected by sporadic and familiar nonautoimmune subclinical hypothyroidism

MicroRNA expression profile helps to distinguish benign and malignant thyroid nodules starting from cells of fine needle aspiration

BiosciAbstracts